GHK-Cu Copper Peptide Serum with GHK-Cu + Hyaluronic Acid
Advanced care for healthy-looking skin: hydrates, improves firmness, rejuvenates
GHK-Cu Copper Peptide Serum with GHK-Cu + Hyaluronic Acid
Paraben-free, dermatologically tested, fragrance-free, cruelty-free copper peptide serum
Silky blue copper peptide serum texture swatch on fingertip
Core dual-effect ingredients: Copper Tripeptide-1 GHK-Cu and Sodium Hyaluronate
How copper tripeptide-1 GHK-Cu works across the skin cell layers
Copper peptide and hyaluronic acid dual-effect combination
Silky, dewy, non-sticky serum texture from the dropper
Lightweight serum absorbs quickly without clogging pores
Macro close-up of copper peptide serum dropper and blue drop
Woman holding a bottle of Zyntra GHK-Cu Copper Peptide Serum
Smiling woman holding Zyntra GHK-Cu Copper Peptide Serum
Three bottles of Zyntra GHK-Cu Copper Peptide Serum

Copper peptides + hyaluronic acid

GHK-Cu Copper Peptide Serum

$67.99$126.87Save 46%
  • The serum is velvety smooth and calming to my skin. No stinging or peeling of any type. I’ve been using it about 10 days and I am seeing the beginning of what seems like rested skin. Will know more soon. Thank you!Jennifer T., verified buyer

Softer-looking lines in 8 weeks. Firmer-looking skin by week 12.

GHK-Cu is a copper peptide your body makes naturally, and makes less of after 20. We pair it with hyaluronic acid, so skin looks plumper and dewier from the first morning while the firmer look builds week by week.

  • Plumper, dewier-looking skin from the first morning
  • Bouncier, firmer-looking skin that keeps building for 12 weeks
  • Gentle enough for every day: fragrance-free and not known to increase sun sensitivity
Save 20% with Auto-RefillNo commitment · Cancel anytime · Refills every 2 months

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Questions about the serum

How do I use it?

Morning and night on clean, dry skin. Smooth it over your face and neck, let it absorb for a minute, then follow with moisturizer. In the morning, finish with sunscreen.

When will I see results?

Hydration you can see from day one. Smoother-looking texture over weeks 3–6, and firmer-looking skin, the slowest change, around weeks 8–12 of daily use. Results vary.

Can I use it with retinol or vitamin C?

Yes, at different times of day: vitamin C in the morning, this serum at night. On retinol nights, alternate: copper peptides one night, retinol the next.

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How does Auto-Refill work?

You pick how often it ships. You are only charged when a refill ships.

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Shipping and returns

Ships in 1–3 business days. 30 days, money back, no forms: email support with your order number.

One serum.

One serum. Three jobs.

A peptide serum for the look of lines, a hydrating serum for glow, and a calmer-looking surface for texture. Normally that’s three bottles. It layers under moisturizer and makeup.

Visibly smoother textureFirmer-looking skin
How does it work?

How does it work?

Right away: hyaluronic acid draws in water, so skin looks plumper the first morning.

Within weeks: the surface looks calmer and more even; makeup stops catching.

Over time: with daily use, skin looks firmer and bouncier. Studies on the peptide measured changes at 8 and 12 weeks.

Copper peptides + hyaluronic acid

What’s inside, and why your skin will love it

GHK-Cu (copper tripeptide-1)

GHK-Cu (copper tripeptide-1)

The peptide studied in human skin for the look of fine lines and firmness.

Hyaluronic acid

Hyaluronic acid

Pulls water into the skin for plumpness from day one.

Silky, non-sticky texture

Silky, non-sticky texture

Absorbs fast and sits well under moisturizer and makeup.

Nothing you don’t need

Nothing you don’t need

Fragrance-free, paraben-free, vegan, cruelty-free.

Benefits that build over time

What changes, and roughly when.

  1. Day 1

    Plump, hydrated skin

    The hyaluronic acid works immediately.

  2. Weeks 3–6

    Smoother texture

    A calmer, more even-looking surface and softer-looking fine lines.

  3. Weeks 6–12

    Skin that bounces back

    The slowest change. Give it 8 to 12 weeks of daily use.

Why Zyntra?

FeatureZyntra serumTypical copper serum
Bottle size60 ml15–30 ml
Hyaluronic acid in the same dropVaries
Fragrance-freeVaries
Vegan and cruelty-freeVaries
Auto-Refill, skip or cancel anytime

Sizes checked Oct 2026: The Ordinary Multi-Peptide + Copper Peptides 1% and Naturium Multi-Peptide Advanced Serum, 30 ml; NIOD Copper Amino Isolate Serum, 15 or 30 ml.

Frequently asked questions

How long does one bottle last?

Each 60 ml bottle lasts about a month, used morning and night. That’s why the 1-bottle Auto-Refill ships every month, and the 2- and 3-bottle plans every 2 and 3 months, so a new bottle arrives as the last one runs out.

Will it make me break out at first?

It can for some people in the first one to three weeks. Start every other night for the first two weeks. If it is still getting worse after six weeks, stop and email us.

Why is it blue?

The blue is the copper bound inside GHK-Cu itself, not an added dye. It absorbs clear.

Is this better than retinol?

Different tools. Copper peptides are gentler and not known to increase sun sensitivity. Plenty of people use both, on alternate nights.

Is it safe for sensitive skin?

It’s fragrance-free and paraben-free. Patch test first. Skip it with a known copper allergy or Wilson’s disease, and check with your doctor if pregnant or breastfeeding.

How does Auto-Refill work?

You get 20% off every order and choose how often it ships. You’re only charged when a refill ships. Skip, pause, change frequency or cancel anytime.

What if it doesn’t work for me?

Email us within 30 days with your order number for a full refund. No forms.